Diodato made his musical debut in 2013 with the song 'E Forse Sono Pazzo' on Le Narcisse Records/Goodfellas. The following year, he took part in the 64th Sanremo Festival in the Newcomer category with the song 'Babilonia', where he came in second place.
Diodato signed with Carosello Records in 2016 and, in January 2017, he released the album Cosa Siamo Diventati, followed by a tour. That same year, he participated in #EveryChildisMyChild - Live for Syria, a project in Vulci organized Italian artists to support the construction of a school in Syria.
The single Cretino Che Sei marked a stylistic turning point in Diodato's career. In December 2017 he won the Critic's Choice at the 68th Sanremo Festival with Roy Paci and the song Adesso. He was again back on the Ariston stage as a guest of Ghemon in 2019 performing Rose Viola with the Calibro 35. He then inaugurated a new phase of his musical career with the songs Il Mercante, Non Ti Amo Più and Che Vita Meravigliosa, which became the soundtrack to Ferzan Ozpetek's new movie La Dea Fortuna.
Diodato won the 70th Sanremo Festival with the song Fai Rumore, a song that has now topped the Italian charts. On Monday 24 February, the Mayor and the Council of Taranto conferred the Civic Merit award to Diodato for paying homage to his city with his Eurovision entry.